R É S U M É
Doc. MVDr. Tomáš Sládek, CSc. Vice President and Chief
Scientific Officer of MEDEA PHARM s.r.o. EDUCATION Doc. Habilitation 3/17/1994 Academic
degree corresponding to Associate Professor of Physiology and Pathophysiology Medical Faculty Masaryk University 662
43 Brno CSc. (corresp. to Ph.D.) diploma 3/15/1985 Postgraduate
course of supervised research (12/79
- 3/85) University of
Veterinary Medicine Palackého Str. 1/3 Brno MVDr. (corresp. to M.V.D.) diploma 3/25/1972 University
level (10/66 - 3/72) University
of Veterinary Medicine Palackého
street 1/3 Brno WORK EXPERIENCE Vice President and Chief Scientific
Officer of MEDEA PHARM s.r.o. 07/1999 – present Srbská
46 612 00 Brno Programme Manager,
Department of Technical Strategy 05/1998 – 02/1999 Headquarters LACHEMA, a.s. Karásek 1 Brno Head of Department of Clinical Pharmacology 10/1995 - 04/1998 Headquarters LACHEMA, a.s. Karásek 1 Brno Associate Professor 3/1994 - 10/1995 Inst. Pathol. Physiol. Medical Faculty Masaryk University 662 43 Brno Visiting Scientist award from East Eur. Exchange
Program of MRC of Canada 1/93 - 12/93 Dept.
Physiol. Medical Faculty University of Ottawa 451 Smyth Road Ottawa, K1H 8M5 Ont. Canada Senior Lecturer 10/1990 - 3/1994 Inst.
Pathol. Physiol. Medical Faculty Masaryk University 662 43 Brno Part-time Expert 10/1990 - 12/1991 Research
Institute of Fine Chemicals LACHEMA n.e. Karásek 1 621 33 Brno Head of Department of Pharmacology and Toxicology 10/1985 - 9/1990 Research
Institute of Fine Chemicals LACHEMA n.e. Karásek 1 621 33 Brno Operating Room Manager 1/1975 – 12/1979 Artificial Heart
Research Center of the Regional Institute of Health affiliated to the
Medical Faculty of Masaryk University in Brno Research Fellow (experimental surgery 8/1972 - 9/1985 Artificial
Heart Research Center of the Regional Institute of Health affiliated to
the Medical Faculty of Masaryk University in Brno MEMBERSHIP IN ACADEMIC BODIES AT MASARYK
UNIVERSITY
Full
Length Papers: 79 Patents: 2 Number
of Citations: 148 LIST OF THE MOST IMPORTANT PUBLICATIONS 1. Sladek T, Sladkova J,
Kolar F, Papousek F, Cicutti N, Korecky B, Rakusan K. The effect of AT1
receptor antagonist on chronic cardiac response to coronary artery
ligation in rats. Cardiovasc Res 1996;31:568–576. [№. of citations: 47] Abstract
Free
Full Text 2. Sladek
T, Gerova M, Znojil V, Devat L. Morphometric
characteristics of cardiac hypertrophy induced by long-term inhibition of
NO synthase. Physiol Res 1996;45(4):335 –338. [№. of citations: 33] Abstract 3. Rakusan
K, Cicutti N, Sladek T. Ischemic heart:
microcirculatory aspects. Adv Exp Med Biol 1996;388:457–461. 4. Filkuka J, Sladek T,
Kleinwächter V, Neuhybel P, Hofirek B, Kiss F. Study
of chronic toxicity of calcium antagonist diltiazem (BLOCALCIN 60
Lachema): Histopathological study on Beagle dogs. Scripta med.
1990;63:463–470. 5. Juraskova V, Sladek T. Antimetastatic activity of diltiazem on LS/BL tumor cells in
liver-tumor-colony assay. Neoplasma 1990;37:343–347. [№. of citations: 4] Abstract 6. Dostal
M, Vasku J, Dolezel S, Pavlicek V, Necas J, Sladek T. [The effect of reperfusion and diltiazem on the extent of
experimental infarct in the dog]. Cesk. Fysiol. 1989;38(6):561–564. 7. Kostal
M, Rajcani J, Sladek T. [Treatment of mice
infected with herpes simplex viruses using acycloguanosine]. Bratisl Lek
Listy 1988;89(7):495–503. 8. Salamoun J, Sprta V,
Sladek T, Smrz M. Determination of acyclovir in
plasma by column liquid chromatography with fluorescence detection. J
Cromatogr Biomed Appl 1987,420:197–202. [№. of citations: 25] 9. Dolezel S, Gerova M,
Hartmannova B, Sladek T, Dostal M, WENDSCHE P, JANECKOVA H, Vasku J. Adrenerge Innervation des Hundeherzens nach einseitiger
Sympathektomie, Verh Anat Ges 1986;80:555–557. 10. Dolezel
S, Vasku J, Hartmannova B, Filkuka J, Cerny J, Dostal M, Sladek T,
Urbanek E. Innervation of atrial stumps in calves
living with the TNS-Brno II artificial heart. Artif. Organs
1985;9(1):53–58. Abstract 11. Sladek T, Filkuka J,
Dolezel S, Vasku J, Hartmannova B, Travnickova J.
The border zone of the early myocardial infarction in dogs: its
characteristics and viability. Basic Res Cardiol 1984;79:344–349. [№. of citations: 6] Abstract 12.
Trbusek V, Fiala V, Vrbova M,
Urbanek P, Vasku J, Urbanek E, Pavlicek V, Sotolova O, Dostal M, Sladek
T. The heart
prosthesis – biocompatibility with living tissue [letter]. Int J Artif
Organs 1984;7:163–164. 13.
Hartmannova B, Vasku J, Dolezel
S, Urbanek E, Filkuka J, Sladek T, Krcek L, Guba P, Dostal M, Cerny J. Mechanisms causing the death
of 8 calves surviving with implanted artificial heart from 31 to 173
days. Exp Pathol 1984;26:221–225. Abstract 14. Vasku
J, Cerny J, Urbanek E, Dostal M, Urbanek P, Guba P, Pavlicek V, Sladek T
Smutny M. A comparative study of a group of eight
calves, surviving longer than 1 month with the total artificial heart.
Artif Organs 1983;7(4): 470–478. [№. of citations: 3] Abstract 15. Dostal M, Vasku J, Cerny J, Guba
P, Pavlicek V, Sladek T, Janeckova H, Sotolova O, Urbanek E. Some problems associated
with the implantation of a cardiac prosthesis and with early
postoperative care in animals with a total artificial heart. Life
Support. Syst 1983;1:281–290. Abstract 16. Dolezel
S, Sladek T, Vasku J. [Histochemical aspects of
experimental myocardial infarct in relation to sympathetic innervation].
Cesk Fysiol 1982;31(6):571–576. 17. Vasku
J, Cerny J, Hanzelka P, Urbanek E, Dostal M, Urbanek P, Guba P, Pavlicek
V, Krcek L, Sladek T, Hartmannova B, Filkuka J, Janeckova H, Sotolova O,
Sotakova E, Dolezel S, Krcma V, Cidl K, Bednarik B. 150-day survival of a calf with a polymethylmethacrylate
total artificial heart: TNS-BRNO-II. Artif Organs 1981;5(4):388–400. [№. of citations: 1] 18. Cerny J, Vasku J, Dostal M, Gregor Z, Hanzelka
P, Wendsche P, Sladek T, Guba P, Pavlicek V, Sotolova O, Urbanek E,
Urbanek P, Krcek L, Janeckova H, Sotakova E, Hartmannova B, Dolezel S. [Surgical aspects of
artificial heart implantation]. Rozhl Chir 1981;60:354–360. 19. Sladek
T, Vasku J, Urbanek E, Filkuka J, Dolezel S, Wendsche P, Hartmannova B,
Sotolova O. Reperfusion of coronary arteries
after temporary occlusion in dogs. J Cardiovasc Surg (Torino)
1980;21(6):695–702. Abstract 20. Dolezel
S, Gerova M, Gero J, Sladek T, Vasku J. Monoaminergic
pathways to the coronary arteries and to the myocardium. Acta Anat (Basel) 1980;108:490–7. [№. of cit.: 3] Abstract 21. Vasku J, Cerny J, Hanzelka
P, Vasku Jan, Urbanek E, Dostal M, Urbanek P, Guba P, Pavlicek V, Krcek
L, Sladek T, Hartmannova B, Filkuka J, Janeckova H, Sotolova O, Sotakova
E, Dolezel S, Krcma V, Cidl K, Bednarik B. The
150-day survival of a calf with the polymetyl matacrylate total
artificial heart – TNS BRNO – II. Artificial Organs 1980;5:388–400. 22. Dolezel S, Gerova M, Gero
J, Sladek T, Vasku J. Adrenergic innervation of
the coronary arteries and the myocardium. Acta Anat 1978;100:306–316. [№. of cit.: 26] Abstract 23.
Sladek T, Filkuka J,
Pejchlova M, Sotolova O, Hartmannova B, Vitek J, Dostal M, Stepanek V,
Urbanek E, Vasku J, Bednarik B. Suppression of
the progress of necrosis after coronary artery ligation in the dog by
pharmacologic interventions. J Cardiovasc Surg (Milano) 1976;17:321–328. Abstract |